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KMID : 0939920180500010111
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대한암학회지
2018 Volume.50 No. 1 p.111 ~ p.117
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Proteomic Biomarkers for Bisphenol A?Early Exposure and Women’s Thyroid Cancer
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Lee Ho-Sun
Kang Yun-Kyeong
Tae Kyung
Bae Gyu-Un
Park Jong-Y.
Cho Yoon-Hee
Yang Mi-Hi
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Abstract
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Purpose: For the target treatment and prevention of women’s increased thyroid cancer, we focused on risks of environmental exposure to endocrine disrupting chemicals, particularly bisphenol A (BPA), and its high susceptible exposure-timing, particularly early exposure in lives.
Materials and Methods: Female ICR mice were exposed to BPA in utero and in early life (15, 75, and 300 mg/L of drinking water via pregnant mice and lactation). We identified BPA-responsive proteins in mice thyroid by two-dimensional gel electrophoresis, image analyses, and electrospray ionization quadrupole time-of-flight mass spectrometry. We further analyzed expression of the BPA-responsive proteins in women thyroid cancer patients (n=28).
Results: We found the altered 17 proteins in BPA dose-dependent manner among the thyroid tissues of offspring mice and identified nine proteins of them, including Anxa6, Atp5b, Hspa5, and Vcp, etc. In addition, we observed the positive association between blood BPA levels and mRNA expression of the ANXA6 and VCP not in normal but thyroid cancer tissues.
Conclusion: Our study provides ANXA6 and VCP as proteomic biomarkers for BPA?early life exposure and their potential for women’s thyroid cancer.
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KEYWORD
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Bisphenol A, Endocrine disruptors, Thyroid neoplasms, Women, Maternal exposure, Proteomics, Annexin A6, Valosin-containing protein
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